Koselugo is a prescription medicine that is used to treat children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cannot be completely removed by surgery. It is not known if Koselugo is safe and effective in children under 2 years of age. Learn more about taking Koselugo.
Koselugo is not chemotherapy. Koselugo is an oral, targeted treatment option proven to shrink PN in children 2 years of age and older with NF1 who have plexiform neurofibromas that cannot be completely removed by surgery.
After prescribing Koselugo, your child’s doctor will monitor his or her response to treatment and perform periodic testing, and will determine the appropriate length of therapy. Treatment duration of Koselugo can be different for every patient, so it’s important to carefully follow the instructions provided by your child’s doctor.
Koselugo is a prescription medicine for children 2 years of age and older with NF1 who have plexiform neurofibromas that cannot be completely removed by surgery. It is available only through specialty pharmacies and is not available at your local retail pharmacy. For more specific information about specialty pharmacies and other distribution channels that carry Koselugo and to learn more about insurance coverage and out-of-pocket costs, visit www.AlexionOneSource.com.
Koselugo is a prescription medicine for children 2 years of age and older with NF1 who have plexiform neurofibromas that cannot be completely removed by surgery. The Alexion OneSource™ program can provide information about financial support and resources that may be available for eligible patients. To learn more, please visit www.AlexionOneSource.com.
Your child’s doctor will decide if Koselugo is right for your child. Koselugo is a prescription medicine that is used to treat children 2 years of age and older with NF1 who have plexiform neurofibromas that cannot be completely removed by surgery. It is not known if Koselugo is safe and effective in children under 2 years of age. Learn about Koselugo.
Your child should take Koselugo exactly as your child’s healthcare provider tells you to and should not change the dose or stop taking Koselugo unless your child’s healthcare provider tells you to.
Your child's healthcare provider may change the dose, temporarily stop, or permanently stop treatment with Koselugo if your child has side effects.
Your child's healthcare provider will decide on the right dose of Koselugo based on their weight or size (body surface area) and how many Koselugo capsules your child should take.
Koselugo should be taken around the same time each day, about 12 hours apart.
Your child must take Koselugo on an empty stomach. Do not let them eat food for 2 hours before the dose and for 1 hour after the dose. Your child should swallow Koselugo capsules whole with water. Do not let them chew, dissolve, or open the capsules.
If your child misses a dose of Koselugo, they should take it as soon as you remember. If it is less than 6 hours before the next scheduled dose, give the next dose at your regular time. Do not make up for the missed dose.
If your child vomits at any time after taking Koselugo, do not give them an additional dose. Give the next dose at your regular time. Learn more about taking Koselugo.
Tell your doctor if your child has trouble swallowing capsules. To learn more or to contact your dedicated Patient Access Navigator, please call 1-888-765-4747, Monday through Friday, 8:30 AM–8 PM ET, or visit www.AlexionOneSource.com. To learn how to help your child take capsules more easily, visit our Dosing Information page.
No, Koselugo capsules must be swallowed whole with water. Do not let your child chew, dissolve, or open a capsule. Tell your child’s doctor if your child has trouble swallowing a capsule. To learn more, visit the Taking Koselugo page.
Koselugo may cause serious side effects, including heart problems, eye problems, severe diarrhea, skin rash, and muscle problems (rhabdomyolysis). Your child’s healthcare provider may change, temporarily stop, or permanently ask your child to stop taking Koselugo if your child has any of these side effects. The most common side effects of Koselugo are vomiting, stomach pain, nausea, dry skin, feeling of tiredness, weakness, or lacking energy, muscle and bone pain, fever, inflammation of the mouth, headache, redness around the fingernails, and itching. These are not all the possible side effects of Koselugo. Please visit our Possible Side Effects page to learn more. Call your child’s doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Of the 33 patients that responded to Koselugo treatment in the clinical trial, approximately one-half saw their tumor volume shrink by at least 20% within 7 months. The time to onset of response ranged from 3.3 months to 19.2 months. It’s important to know that results are different for each patient. Your child’s experience may be different. Your child’s doctor will determine if Koselugo is working for your child. Learn the results of pediatric patients taking Koselugo in a clinical study.
If your child misses a dose, they should take it as soon as you remember. If it is less than 6 hours before the next scheduled dose, give the next dose at the regular time. Do not make up for the missed dose. If your child vomits at any time after taking Koselugo, they should not take an additional dose. The next dose should be taken at the regular time. To learn more about taking Koselugo, visit our Taking Koselugo page.
Your child must take Koselugo on an empty stomach. Your child should not eat 2 hours before each dose or 1 hour after each dose because food can affect the absorption of Koselugo. To learn more about taking Koselugo, visit our Taking Koselugo page.
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