Koselugo comes with a team

Caleb, a 7-year-old living with NF1 PN, playing in a park

Caleb, age 7, living with NF1 PN.
Caleb is not currently taking Koselugo.

Support specialists are ready to help

Alexion is committed to providing free assistance to you and your family with our team of support specialists. Our specialists will be available during every step of the journey, from considering Koselugo to being treated with Koselugo.

Your dedicated PEM is your partner

Your dedicated Patient Education Manager (PEM) is available to meet in person or virtually. If you have questions about NF1 plexiform neurofibromas or how Koselugo works, or just need someone to listen, your PEM is here for you.

PEMs engage with the community by:

hosting national educational webinars
partnering with patient advocacy groups
coordinating one-on-one or group interactions

Connect with a PEM and request a Parent Readiness Kit

Connect with a PEM today for one-on-one support and education. Request the Parent Readiness Kit to help you gain a greater understanding of NF1 plexiform neurofibromas and how they can affect your child.

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Access personalized support and care

When your loved one is prescribed Koselugo, you may be able to enroll in Alexion's free, personalized support program called OneSource^TM.

OneSource Support Services:

Once your child has been prescribed Koselugo, a dedicated Alexion Case Manager is ready to help your family navigate the logistics of starting and staying on treatment. They can help by:

navigating insurance coverage
answering treatment questions
offering practical support
addressing financial concerns
assisting in avoiding treatment interruptions

OneSource CoPay Program:

The OneSource CoPay Program helps cover some out-of-pocket costs for eligible Koselugo patients.

You can pay as little as $0 for Koselugo if you have commercial insurance.^*

To get started, you must:

Be signed up for patient services through OneSource
Have commercial insurance (not part of a federal- or state-funded healthcare program)
Be prescribed Koselugo for an FDA-approved indication
Reside in the United States or its territories

Learn if you're eligible.

^*Please refer to the full CoPay Terms and Conditions for additional eligibility requirements.

Enroll in OneSource today

To learn more or to contact your dedicated Case Manager, click on the link below, or call
1-888-765-4747, Monday through Friday, 8:30 AM–8 PM ET.

Connect now

important safety information

What are the possible side effects of Koselugo?

Koselugo may cause serious side effects, including:

Heart problems. Koselugo can lower the amount of blood pumped by your heart, which is common and can also be severe. Your healthcare provider will do tests before and during treatment to check how well your heart is working. Tell your healthcare provider right away if you get any of the following signs or symptoms: persistent coughing or wheezing, shortness of breath, swelling of your ankles and feet, tiredness, increased heart rate.
Eye problems. Koselugo can cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment. Tell your healthcare provider right away if you get any of the following signs or symptoms: blurred vision, loss of vision, dark spots in your vision (floaters), other changes to your vision.
Severe diarrhea. Diarrhea is common with Koselugo and can also be severe. Tell your healthcare provider right away the first time that you get diarrhea during treatment. Your healthcare provider may give you medicine to help control your diarrhea and may tell you to drink more fluids.
Skin rash. Skin rashes are common with Koselugo and can also be severe. Tell your healthcare provider if you get any of the following signs or symptoms: rash that covers a large area of your body, peeling skin, blisters.
Muscle problems (rhabdomyolysis). Muscle problems are common with Koselugo and can also be severe. Treatment with Koselugo may increase the level of a muscle enzyme in your blood called creatine phosphokinase (CPK) and may be a sign of muscle damage. Your healthcare provider should do a blood test to check your muscle enzyme levels of CPK before you start taking Koselugo and during treatment. Tell your healthcare provider right away if you get any of the following signs or symptoms: muscle aches or pain; muscle spasms and weakness; dark, reddish urine.

Before taking Koselugo, tell your healthcare provider about all your medical conditions, including if you:

have heart problems.
have eye problems.
have liver problems.
are pregnant or plan to become pregnant. Koselugo can harm your unborn baby. Your healthcare provider should verify if you/your partner are pregnant before beginning treatment. Ensure you/your partner use effective birth control (contraception) during treatment and for 1 week after your last dose if there is possibility pregnancy could occur. Tell your healthcare provider right away if you/your partner think you may be pregnant.
are breastfeeding or plan to breastfeed. It is not known if Koselugo passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription, over-the-counter medicines, vitamins, or herbal supplements. Especially tell your healthcare provider if you are taking aspirin, blood thinners, or other medicines to treat blood clots. Koselugo contains vitamin E, which may increase risk of bleeding.

What should I avoid while taking Koselugo?

Do not drink grapefruit juice, eat grapefruit, or take supplements with grapefruit or St. John’s Wort during treatment.

Most common side effects include: vomiting, stomach-area pain, nausea, dry skin, muscle and bone pain, feeling of tiredness or lacking energy, fever, sores in your mouth, headache, redness around the fingernails, itching.

These are not all the possible side effects of Koselugo. Call your healthcare provider for medical advice about side effects. Your healthcare provider may change your dose, temporarily stop, or permanently ask you to stop taking Koselugo if you have any of these side effects. You may report side effects to AstraZeneca at 1-800-236-9933 or at https://
us-aereporting.astrazeneca.com or FDA at
1-800-FDA-1088 or www.fda.gov/medwatch.

Indication

What is Koselugo?

Koselugo is a prescription medicine that is used to treat children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cannot be completely removed by surgery. It is not known if Koselugo is safe and effective in children under 2 years of age.

Please see Patient Information in the full Prescribing Information for Koselugo (selumetinib).

All families shown in this website have been compensated by Alexion, unless otherwise noted.