WHAT IS NEUROFIBROMATOSIS TYPE 1 (NF1)?

NF1 is a rare, progressive condition caused by a mutation or flaw in a particular gene. NF1 is usually diagnosed in early childhood. It appears in an estimated 1 out of every 3000 infants worldwide.

WHAT ARE PLEXIFORM NEUROFIBROMAS (PN)?

of children with NF1 may develop benign (noncancerous) tumors called plexiform neurofibromas or plexiform tumors, which grow along nerves.

Where do NF1 plexiform neurofibromas occur?

These tumors can grow on any nerve in the body and can be large or small in size.

Discover Koselugo’s PROVEN ability to treat NF1 plexiform neurofibromas
Learn about Koselugo

HOW ARE NF1 PLEXIFORM NEUROFIBROMAS (PN) TREATED?

Which doctors and healthcare specialists treat pediatric NF1 plexiform neurofibromas (PN)?

NF1 plexiform neurofibromas are usually treated by a team of healthcare specialists, including neuro-oncologists, oncologists, neurologists, geneticists, surgeons, and others who specialize in treating symptoms related to this disease.

The location and symptoms of your child’s plexiform neurofibromas will help determine which doctors are best to see for treatment.

Why can’t some NF1 plexiform neurofibromas (PN) be completely removed by surgery?

Surgery for NF1 plexiform neurofibromas may not be recommended by your child’s healthcare provider. One reason is plexiform neurofibromas may be closely intertwined with critical nerves, many blood vessels, and located near major organs. Also, PN may not be completely removed by surgery.

Are there any other ways to treat NF1 plexiform neurofibromas (PN)?

Your child’s doctor may prescribe therapies or medicines to help relieve symptoms of NF1 plexiform neurofibromas (PN).

Before Koselugo, there was no FDA-approved medication proven to reduce the size of NF1 plexiform neurofibromas (PN).
Ask your child’s doctor about Koselugo—a prescription treatment for NF1 PN patients who have symptomatic, inoperable plexiform neurofibromas. What is Koselugo?

WHAT ARE SOME WAYS FAMILIES CAN NAVIGATE NF1 PN?

Plexiform neurofibromas (PN) can cause a lot of uncertainty. Creating daily routines for children can help them feel secure and give them a positive sense of control.

Building a supportive home environment in which all family members are treated equally with respect and acceptance can benefit not only the child with NF1 plexiform neurofibromas, but also siblings, who may feel they’re getting less attention.

Making the transition from childhood to teenage years can be especially difficult when living with NF1 PN. Helping your child gradually take more control of their health care, medications, and treatment decisions can encourage responsibility and help them feel empowered.

Ask your child's doctor if Koselugo is right for your child Get to know Koselugo

IMPORTANT SAFETY INFORMATION

Before taking Koselugo, tell your healthcare provider about all of your medical conditions, including if you:

  • have heart problems
  • have eye problems
  • have liver problems
  • are pregnant or plan to become pregnant. Koselugo can harm your unborn baby
    • Females who could become pregnant and males with female partners who could become pregnant should use effective birth control (contraception) during treatment with Koselugo and for 1 week after your last dose
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Koselugo
  • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Koselugo
    • Do not breastfeed during treatment with Koselugo and for 1 week after your last dose
    • Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements. Especially tell your healthcare provider if you are taking aspirin, blood thinners, or other medicines to treat blood clots. Koselugo contains vitamin E, which may increase your risk of bleeding.

Koselugo may cause serious side effects, including:
Heart problems. Koselugo can lower the amount of blood pumped by your heart, which is common and can also be severe. Your healthcare provider will do tests before and during treatment with Koselugo to check how well your heart is working. Tell your healthcare provider right away if you get any of the following signs or symptoms:

  • persistent coughing or wheezing
  • shortness of breath
  • swelling of your ankles and feet
  • tiredness
  • increased heart rate

Eye problems. Koselugo can cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment with Koselugo. Tell your healthcare provider right away if you get any of the following signs or symptoms:

  • blurred vision
  • loss of vision
  • dark spots in your vision (floaters)
  • other changes to your vision

Severe diarrhea. Diarrhea is common with Koselugo and can also be severe. Tell your healthcare provider right away the first time that you get diarrhea during treatment with Koselugo. Your healthcare provider may give you medicine to help control your diarrhea and may tell you to drink more fluids.

Skin rash. Skin rashes are common with Koselugo and can also be severe. Tell your healthcare provider if you get any of the following signs or symptoms:

  • rash that covers a large area of your body
  • peeling skin
  • blisters

Muscle problems (rhabdomyolysis). Muscle problems are common with Koselugo and can also be severe. Treatment with Koselugo may increase the level of a muscle enzyme in your blood, which may be a sign of muscle damage. Your healthcare provider should do a blood test to check your muscle enzyme levels before you start taking Koselugo and during treatment. Tell your healthcare provider right away if you get any of the following signs or symptoms:

  • muscle aches or pain
  • muscle spasms and weakness
  • dark, reddish urine

Your healthcare provider may change your dose, temporarily stop, or permanently ask you to stop taking Koselugo if you have any of these side effects.

The most common side effects of Koselugo are:

  • vomiting
  • stomach-area pain
  • nausea
  • dry skin
  • muscle and bone pain
  • feeling of tiredness or lacking energy
  • fever
  • sores in your mouth
  • headache
  • redness around the fingernails
  • itching

These are not all the possible side effects of Koselugo.

INDICATION

What is Koselugo?

Koselugo is a prescription medicine that is used to treat children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cannot be completely removed by surgery.

It is not known if Koselugo is safe and effective in children under 2 years of age.

You may report side effects related to AstraZeneca products by clicking here.

  • are pregnant or plan to become pregnant. Koselugo can harm your unborn baby
    • Females who could become pregnant and males with female partners who could become pregnant should use effective birth control (contraception) during treatment with Koselugo and for 1 week after your last dose
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Koselugo
  • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Koselugo
    • Do not breastfeed during treatment with Koselugo and for 1 week after your last dose
    • Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements. Especially tell your healthcare provider if you are taking aspirin, blood thinners, or other medicines to treat blood clots. Koselugo contains vitamin E, which may increase your risk of bleeding.

Koselugo may cause serious side effects, including:
Heart problems. Koselugo can lower the amount of blood pumped by your heart, which is common and can also be severe. Your healthcare provider will do tests before and during treatment with Koselugo to check how well your heart is working. Tell your healthcare provider right away if you get any of the following signs or symptoms:

  • persistent coughing or wheezing
  • shortness of breath
  • swelling of your ankles and feet
  • tiredness
  • increased heart rate

Eye problems. Koselugo can cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment with Koselugo. Tell your healthcare provider right away if you get any of the following signs or symptoms:

  • blurred vision
  • loss of vision
  • dark spots in your vision (floaters)
  • other changes to your vision

Severe diarrhea. Diarrhea is common with Koselugo and can also be severe. Tell your healthcare provider right away the first time that you get diarrhea during treatment with Koselugo. Your healthcare provider may give you medicine to help control your diarrhea and may tell you to drink more fluids.

Skin rash. Skin rashes are common with Koselugo and can also be severe. Tell your healthcare provider if you get any of the following signs or symptoms:

  • rash that covers a large area of your body
  • peeling skin
  • blisters

Muscle problems (rhabdomyolysis). Muscle problems are common with Koselugo and can also be severe. Treatment with Koselugo may increase the level of a muscle enzyme in your blood, which may be a sign of muscle damage. Your healthcare provider should do a blood test to check your muscle enzyme levels before you start taking Koselugo and during treatment. Tell your healthcare provider right away if you get any of the following signs or symptoms:

  • muscle aches or pain
  • muscle spasms and weakness
  • dark, reddish urine

Your healthcare provider may change your dose, temporarily stop, or permanently ask you to stop taking Koselugo if you have any of these side effects.

The most common side effects of Koselugo are:

  • vomiting
  • stomach-area pain
  • nausea
  • dry skin
  • muscle and bone pain
  • feeling of tiredness or lacking energy
  • fever
  • sores in your mouth
  • headache
  • redness around the fingernails
  • itching

These are not all the possible side effects of Koselugo.

INDICATION

What is Koselugo?

Koselugo is a prescription medicine that is used to treat children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cannot be completely removed by surgery.

It is not known if Koselugo is safe and effective in children under 2 years of age.

You may report side effects related to AstraZeneca products by clicking here.